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(ICH)新研究發現高度稀釋療劑對乳腺癌細胞有細胞毒性作用

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Έρως 發表於 2014-8-9 08:59:00 | 顯示全部樓層 |閱讀模式
於 2014年 8 月 9 日 取自 http://www.homeopathy-ich.org/news.html

2013年7月25日

新研究發現高度稀釋療劑對乳腺癌細胞有細胞毒性作用

摘要。

在疾病的處理和癌症治療使用高度稀釋的天然產品,已經產生了很大的關注和爭議。我們進行了試管內之研究,以確定在印度診所處方的產品是否對乳腺癌細胞系產生任何影響。

我們研究了4種高度稀釋療劑(癌體,商陸,毒人參和側柏),針對於兩種人類乳腺癌細胞系(MCF-7和MDA-MB-231)和從無限增殖化乳腺上皮細胞(HMLE)衍生的細胞系。

那四種療劑都能夠對兩種乳腺癌細胞系發揮出優越的細胞毒性作用,引起細胞週期的延遲/停滯和細胞凋亡。這些作用伴隨著細胞週期調節蛋白模式的改變,包括磷酸化Rb的下調和CDK p27抑製劑的上調,CDK p27抑製劑很可能是負責細胞週期的延遲/阻滯,以及誘導細胞凋亡級聯反應,從胱天蛋白酶7的激活和被處理的細胞中PARP的分裂中已清晰可見。

該研究結果表明,這些天然產物在高度稀釋劑量形式的生物活性。以另外的細胞系和動物測試組別進一步深入研究必定能夠發現這些藥物的臨床適用性。

完整版的研究報告可以在這裡下載:
http://www.spandidos-publications.com/ijo/article.jsp?article_id=ijo_36_2_395


英文版本:

25 July 2013

New study finds ultra-diluted remedies have cytotoxic effects on breast cancer cells

Abstract. The use of ultra-diluted natural products in the management of disease and treatment of cancer has generated a lot of interest and controversy. We conducted an in vitro study to determine if products prescribed by a clinic in India have any effect on breast cancer cell lines. We studied four ultra-diluted remedies (Carcinosin, Phytolacca, Conium and Thuja) against two human breast adenocarcinoma cell lines (MCF-7 and MDA-MB-231) and a cell line derived from immortalized normal human mammary epithelial cells (HMLE). The remedies exerted preferential cytotoxic effects against the two breast cancer cell lines, causing cell cycle delay/arrest and apoptosis. These effects were accompanied by altered expression of the cell cycle regulatory proteins, including down-regulation of phosphorylated Rb and upregulation of the CDK inhibitor p27, which were likely responsible for the cell cycle delay/arrest as well as induction of the apoptotic cascade that manifested in the activation of caspase 7 and cleavage of PARP in the treated cells. The findings demonstrate biological activity of these natural products when presented at ultra-diluted doses. Further indepth studies with additional cell lines and animal models arewarranted to explore the clinical applicability of these agents.

A full version of the study can be downloaded here:
http://www.spandidos-publications.com/ijo/article.jsp?article_id=ijo_36_2_395

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