順勢療法討論區 Homeopathy Discuss!

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admin 發表於 2015-6-5 17:00:17 | 顯示全部樓層 |閱讀模式
DAY 1 – 5 June 2015 ( 930-1030 )
Homeopathy research – the state of play and the way forward
順勢療法的研究 -戲劇的局勢和前進的方向

Prof Paolo Bellavite ,
Italy. Basic research on homeopathic principlesProf Paolo Bellavite ***,                                        
來自意大利. 順勢療法原則的基礎研究
Professor of General Pathology, School of Medicine,  Verona University, Italy
Prof. Bellavite is a teacher and researcher  specialising in Clinical and Laboratory Haematology. His research focuses on  molecular and cellular aspects of inflammation, with particular regard to the  structure, biochemistry and function (normal and pathological) of  granulocytes, macrophages and platelets.
Research area
Bellavite P, Signorini A, Marzotto M, Moratti E, Bonafini  C, Olioso D.
Cell sensitivity, non-linearity and inverse effects. Homeopathy.  2015 Apr;104(2):139-160. doi: 10.1016/j.homp.2015.02.002. Epub 2015 Mar 12.  Review.
It has been claimed that the homeopathic principle  of 'similarity' (or 'similia') and the use of individualized remedies in  extremely low doses conflicts with scientific laws, but this opinion can be  disputed on the basis of recent scientific advances. Several mechanisms to  explain the responsiveness of cells to ultra-low doses and the similarity as  inversion of drug effects, have again been suggested in the framework of  hormesis and modern paradoxical pharmacology.
Low doses or high dilutions of a drug interact only  with the enhanced sensitivities of regulatory systems, functioning as minute  harmful stimuli to trigger specific compensatory healing reactions. Here we  review hypotheses about homeopathic drug action at cellular and molecular  levels, and present a new conceptual model of the principle of similarity  based on allosteric drug action.
While many common drugs act through orthostatic  chemical interactions aimed at blocking undesired activities of enzymes or  receptors, allosteric interactions are associated with dynamic conformational  changes and functional transitions in target proteins, which enhance or  inhibit specific cellular actions in normal or disease states. The concept of  allostery and the way it controls physiological activities can be broadened  to include diluted/dynamized compounds, and may constitute a working  hypothesis for the study of molecular mechanisms underlying the inversion of  drug effects.

Bellavite P, Marzotto M, Olioso D, Moratti E, Conforti A.  High-dilution effects revisited. 1. Physicochemical aspects. Homeopathy. 2014 Jan;103(1):4-21. doi:  10.1016/j.homp.2013.08.003. Review.
重新審視高稀釋效應 1---- 物理化學方面
Several lines of evidence suggest that homeopathic  high dilutions (HDs) can effectively have a pharmacological action, and so  cannot be considered merely placebos. However, until now there has been no  unified explanation for these observations within the dominant paradigm of  the dose–response effect. Here the possible scenarios for the physicochemical  nature of HDs are reviewed. A number of theoretical and experimental  approaches, including quantum physics, conductometric and spectroscopic  measurements, thermoluminescence, and model simulations investigated the  peculiar features of diluted/succussed solutions.
The heterogeneous composition of water could be  affected by interactive phenomena such as coherence, epitaxy and formation of  colloidal nanobubbles containing gaseous inclusions of oxygen, nitrogen,  carbon dioxide, silica and, possibly, the original material of the remedy. It  is likely that the molecules of active substance act as nucleation centres,  amplifying the formation of supramolecular structures and imparting order to  the solvent.
Three major models for how this happens are  currently being investigated: the water clusters or clathrates, the coherent  domains postulated by quantum electrodynamics, and the formation of  nanoparticles from the original solute plus solvent components.
目前正在研究引致這種情況發生的三個主要模式:包括水簇或水的籠形物、量子電動力假設的凝聚域(coherent domains)、以及從原來的物質加溶劑組分形成的納米顆粒。
Other theoretical approaches based on quantum  entanglement and on fractal-type self-organization of water clusters are more  speculative and hypothetical. The problem of the physicochemical nature of  HDs is still far from to be clarified but current evidence strongly supports  the notion that the structuring of water and its solutes at the nanoscale can  play a key role.

Bellavite P, Marzotto M, Olioso D, Moratti E, Conforti A.  High-dilution effects revisited. 2. Pharmacodynamic mechanisms. Homeopathy.  2014 Jan;103(1):22-43. doi: 10.1016/j.homp.2013.08.002. Review.
重新審視高稀釋效應 2----藥效學機制
The pharmacodynamics aspects of homeopathic remedies  are appraised by laboratory studies on the biological effects at various  levels (cellular, molecular and systemic). The major question is how these  medicines may work in the body. The possible answers concern the  identification of biological targets, the means of drug–receptor  interactions, the mechanisms of signal transmission and amplification, and  the models of inversion of effects according to the traditional ‘simile’  rule.
These problems are handled by two experimental and  theoretical lines, according to the doses or dilutions considered (low-medium  versus high dilutions).
Homeopathic formulations in low-medium dilutions,  containing molecules in the range of ultra-low doses, exploit the extreme  sensitivity of biological systems to exogenous and endogenous signals. Their  effects are interpreted in the framework of hormesis theories and paradoxical  pharmacology.
The hypotheses regarding the action mechanisms of  highly diluted/dynamized solutions (beyond Avogadro–Loschmidt limit)  variously invoke sensitivity to bioelectromagnetic information, participation  of water chains in signalling, and regulation of bifurcation points of  systemic networks. High-dilution pharmacology is emerging as a pioneering  subject in the domain of nanomedicine and is providing greater plausibility  to the puzzling claims of homeopathy.

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